Human Metabolomics

37. Schiborr, C., Schwamm, D., Kocher, A., Rimbach, G., Eckert, G. P., & Frank J. (2013) The senescence-accelerated mouse - prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals. Pharmacol Res (accepted for publication), IF 4.436

36. Eckert, G. P., Schiborr, C., Hagl, S., Abdel-Kader, R., Müller, W. E., Rimbach, G., & Frank, J. (2013). Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8. Neurochemistry International 65: 595-602, IF 2.857.

35. Podszun, M. C., Grebenstein, N., Hofmann, U., & Frank, J. (2013). High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs. Toxicology and Applied Pharmacology 266: 452-458, IF 4.447.

34. Bayram, B., Ozcelik, B., Frank, J., & Rimbach, G. (2013). A Validated Method for the Determination of Selected Phenolics in Olive Oil Using High-Performance Liquid Chromatography with Coulometric Electrochemical Detection and a Fused-Core Colum. Food Chemistry 138: 1663-1669, IF 3.655.

33. Bayram, B., Esatbeyoglu, T., Schulze, N., Ozcelik, B., Frank, J., & Rimbach, G. (2012). Comprehensive Analysis of Polyphenols in 55 Extra Virgin Olive Oils by HPLC-ECD and Their Correlation with Antioxidant Activities. Plant Foods for Human Nutrition 67: 326-336, IF 2.505.  

32. Bayram, B., Nikolai, S., Huebbe, P., Ozcelik, B., Grimm, S., Grune, T., Frank, J., & Rimbach, G. (2012). Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence accelerated mouse prone 8. Age (published online), IF 3.948.

31. Grebenstein, N. & Frank, J. (2012) Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid-chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver. J Chromatogr A 1243: 39-46, IF 4.531. 

30. Egert, S., Tereszczuk, J., Wein, S., Müller, M.J., Frank, J., Rimbach, G. & Wolffram, S. (2012) Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. Eur J Nutr 52: 281-288, IF 2.750. 

29. Bayram, B., Ozcelik, B., Grimm, S., Roeder, T., Schrader, C., Ernst, I., Wagner, A., Grune, T., Frank, J. & Rimbach, G.  (2012). A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Research 15: 71-81, IF 3.826.

28. Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanovic, I., Laue, C., Winkler, P., Rüfer, C., Frank, J., Boesch-Saadatmandi, C., Rimbach, G. & Schrezenmeir, J. (2013). Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. Nutrition, Metabolism and Cardiovascular Disease 23: 403-409 , IF 3.731.

27. Boesch-Saadatmandi, C., Rimbach, G., Jungblut, A. & Frank, J. (2011) Comparison of tetrahydrofuran, fetal calf serum, and Tween 40 for the delivery of astaxanthin and canthaxanthin to HepG2 cells. Cytotechnology 63: 89-98, IF 1.207.

26. Schrader, C., Schiborr, C., Frank, J. & Rimbach, G. (2011) Curcumin induces paraoxonase-1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Brit J Nutr 105: 167-170, IF 3.072.

25. Schiborr, C., Eckert, G. P., Weissenberger, J., Müller, W. E., Schwamm, D., Grune, T., Rimbach, G. & Frank, J. (2010) Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharmaceut Biotechnol 11: 861-867, IF 3.455.

24. Schiborr, C., Eckert, G. P., Rimbach, G. & Frank, J. (2010) A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 397: 1917-25, IF 3.841. 

23. Fischer, A., Gaedicke, S., Frank, J., Döring, F. & Rimbach, G. (2010) Dietary vitamin E deficiency does not affect global and specific DNA methylation pattern in rat liver. Brit J Nutr 104: 935-940, IF 3.072.

22. Egert, S., Bosy-Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta-Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G., Wolffram, S. & Müller, M. J. (2009) Quercetin reduces systolic blood pressure and plasma oxidized LDL concentrations in overweight subjects with a high-CVD-risk phenotype: a double-blinded, placebo-controlled crossover study. Brit J Nutr 102: 1065-1074, IF 3.446.

21. Augustin, K., Frank, J., Augustin, S., Langguth, P., Öhrvik, V., Witthöft, C., Rimbach, G. & Wolffram, S. (2009) Green tea extracts lower 5-methyltetrahydrofolate in rats only at very high dietary concentrations and do not affect folate concentrations in a human pilot study. J Physiol Pharmacol 60: 103-108, IF 2.631.

20. Wiegand, H., Bösch-Saadatmandi, C., Wein, S., Wolffram, S., Frank, J. & Rimbach, G. (2010) Dietary flavonoids do not affect vitamin E status in growing rats. J Anim Phsyiol Anim Nutr 94: 307-318 (published online in 2009), IF 1.106.

19. Gaedicke, S., Zhang, X., Huebbe, P., Boesch-Saadatmandi, C., Lou, Y., Wiswedel, I., Gardemann, A., Frank, J. & Rimbach, G. (2009) Dietary vitamin E, brain redox status and expression of Alzheimer’s disease relevant genes in rats. Brit J Nutr 102: 398-406, IF 3.446.

18. Frank, J., George, T. W., Lodge, J. K., Rodriguez-Mateos, A., Spencer, J. P. E., Minihane, A. M., & Rimbach, G. (2009) Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease-risk biomarkers in healthy men. J Nutr 139: 58-62, IF 3.647.

17. Gaedicke, S., Zhang, X., Schmelzer, C., Lou, Y., Doering, F., Frank, J. & Rimbach, G. (2008) Vitamin E dependent microRNA regulation in rat liver. FEBS Lett 582: 3542-3546, IF 3.264. 

16. Egert, S., Wolffram, S., Bosy-Westphal, A., Bösch-Saadatmandi, C., Wagner, A., Frank, J., Rimbach, G. & Müller, M. J. (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138: 1615-1621, IF 3.647.

15. Frank, J., Lee, S., Leonard, S. W., Atkinson, J. K., Kamal-Eldin, A. & Traber, M. G. (2008) Sex differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am J Clin Nutr 87: 1723-1729, IF 6.740.

14. Augustin, K., Blank, R., Boesch-Saadatmandi, C., Frank, J., Wolffram, S. & Rimbach, G. (2008) Dietary green tea polyphenols do not affect vitamin E-status, antioxidant capacity and meat quality of growing pigs. J Anim Physiol Anim Nutr 92: 705-711, IF 0.911.

13. Jofre-Monseny, L., Huebbe, P., Stange, I., Boesch-Saadatmandi, C., Frank, J., Jackson, K., Minihane, A. M. & Rimbach, G. (2007) Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein in apoE3 and apoE4 targeted replacement mice. Brit J Nutr 100: 44-53, IF 2.339. 

12. Moazzami, A. A., Frank, J., Lundh, T., Vessby, B. & Kamal-Eldin, A. (2007) Dietary Phytosterols Inhibit the Lipid Modulating Effects of Sesamin in Rats. Curr Topics Nutraceut Res 5: 93-98, IF 0.529.

11. Frank, J., Budek, A., Lundh, T., Parker, R. S., Swanson, J. E., Lourenco, B., Gago, J., Laranjinha, J., Vessby, B. & Kamal-Eldin, A. (2006) Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro. J Lipid Res 47: 2718-2725, IF 4.357. 

10. Hundhausen, C., Frank, J., Rimbach, G., Stoecklin, E., Muller, P. Y. & Barella, L. (2006) Effect of Vitamin E on Cytochrome P450 mRNA Levels in Cultured Hepatocytes (HepG2) and in Rat Liver. Cancer Genomics & Proteomics 3: 183-190.

9. Müller, P.Y., Netscher, T., Frank, J., Stöcklin, E., Rimbach, G., & Barella, L. (2005) Comparative Quantification of Pharmacodynamic Parameters of Chiral Compounds by Global Gene Expression Profiling. J Plant Physiol 162: 811-817, IF 1.403.

8. Frank, J., Kamal-Eldin, A. & Traber, M. G. (2004) Consumption of Sesame Oil Muffins Decreases the Urinary Excretion of γ-Tocopherol Metabolites in Humans. Ann N Y Acad Sci 1031: 365-367, IF 1.789.

7. Frank, J., Eliasson, C., Leroy-Nivard, D., Budek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats. Brit J Nutr 92: 169-176, IF 2.710.

6. Frank, J., Sundberg, B., Kamal-Eldin, A., Vessby, B. & Åman, P. (2004) Yeast-Leavened Oat Breads with High or Low Molecular Weight β-Glucan Do Not Differ in Their Effects on Blood Concentrations of Lipids, Insulin, or Glucose in Humans. J Nutr 134: 1384-1388, IF 3.245.

5. Ross, A. B., Chen, Y., Frank, J., Swanson, J. E., Parker, R. S., Kozubek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Cereal Alkylresorcinols Elevate γ-Tocopherol Levels in Rats and Inhibit γ-Tocopherol Metabolism In Vitro. J Nutr 134: 506-510, IF 3.245.

4. Frank, J., Lundh, T., Parker, R. S., Swanson, J. E., Vessby, B. & Kamal-Eldin, A. (2003) Dietary (+)-Catechin and BHT Markedly Increase α-Tocopherol Concentrations in Rats by a Tocopherol-ω-Hydroxylase-Independent Mechanism. J Nutr 133: 3195-3199, IF 3.321.

3. Frank, J., Kamal-Eldin, A., Razdan, A., Lundh, T. & Vessby, B. (2003) The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenic acid increase vitamin E and cholesterol concentrations in Sprague-Dawley rats. J Agric Food Chem 51: 2526-2531, IF 2.102. 

2. Frank, J., Kamal-Eldin, A., Lundh, T., Määttä, K., Törrönen, R. & Vessby, B. (2002) Effects of Dietary Anthocyanins on Tocopherols and Lipids in Rats. J Agric Food Chem 50: 7226-7230, IF 1.915.

1. Kamal-Eldin, A., Frank, J., Razdan, A., Tengblad, S., Basu, S. & Vessby, B. (2000) Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 35: 427-435, IF 1.769. 

6. Frank, J., Chin, D., Schrader, C., Eckert, G.P. & Rimbach, G. (2012) Do tocotrienols have potential as neuroprotective dietary factors? Ageing Research Reviews 11: 163-180, IF 6.174.

5. Frank, J. & Rimbach, G. (2009) Vitamin E in disease prevention – a critical appraisal of vitamin E supplementation trials. Aktuelle Ernährungsmedizin 34: 131-140.

4. Rimbach, G., Boesch-Saadatmandi, C., Frank, J., Fuchs, D., Wenzel, U., Daniel, H., Hall, W. & Weinberg, P. D. (2007) Dietary isoflavones in the prevention of cardiovascular disease – A molecular perspective. Food Chem Toxicol 46: 1308-1319, IF 2.114.

3. Frank J. (2007) Einfluss von Nahrungspolyphenolen auf den Vitamin-E-Status (Influence of dietary polyphenols on vitamin E-status). Ernährungs-Umschau: 54:52-9.

2. Frank, J., de Pascual Teresa, S. & Rimbach, G. (2006) Nutrigenomics – new frontiers in antioxidant research. Food Sci Technol Bull: Functional Foods 3 (1) 1-12.

1. Frank, J. (2005) Beyond vitamin E supplementation: An alternative strategy to improve vitamin E status. J Plant Physiol 162: 834-843, IF 2.500.

2. Kocher, A., Schiborr, C., Weber, D., Grune, T. & Frank, J. (2012) The bioavailability and antioxidant activity of curcuminoids and carotenoids in humans. In: "Food Oxidants and Antioxidants: Chemical, Biological, and Functional Properties", Bartosz, G., ed., CRC Press (ISBN 978-1-439-88241-2, in press).  

1. Frank, J. & Rimbach, G. (2009) Nutrigenomics. In: “Chemoprevention of Cancer and DNA Damage by Dietary Factors”, Knasmüller, S., DeMarini, D. M., Johnson, I. T. & Gerhäuser, C., eds., Wiley-VCH (ISBN: 978-3-527-32058-5): 303-333.

Frank, J. (2004) Dietary Phenolic Compounds and Vitamin E Bioavailability - Model studies in rats and humans.Doctoral dissertation.  Department of Food Science, Swedish University of Agricultural Sciences (SLU). Acta Universitatis Agriculturae Suecia. Agraria vol. 446. ISSN 1401-6249, ISBN 91-576-6453-6.URL: http://diss-epsilon.slu.se/archive/00000558/