His research interests lie in factors that determine the absorption, metabolism, and elimination of the different vitamin E congeners and phytochemicals (such as curcuminoids and flavonoids) and in developing novel strategies to overcome the low intrinsic oral bioavailability of phytochemicals, as well as in understanding the biological activities of these potentially health-beneficial bioactives.
The long chain α–tocopherol metabolite α-13’-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180.
Transepithelial transport of curcumin in Caco-2 cells is significantly enhanced by micellar solubilisation.
Intratumoral concentrations and effects of orally administered micellar curcuminoids in glioblastoma patients.
Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidaemic individuals
Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice
Professor Frank was invited to appear as a nutrition expert on the German TV program planet wissen.
REDOX BIOLOGY MEETS NUTRITION
Impressions from the joint conference REDOX BIOLOGY MEETS NUTRITION of the Society for Free Radical Research - Europe and the Society of Nutrition and Food Science, which was organised and chaired by Prof Frank. The conference program featured award lectures by Prof Barry Halliwell, the first scientist to give the SNFS Advances in Nutrition Research Lecture, Prof Enrique Cadenas, Prof Randal Kaufman and many more esteemed scientists.
The first nutrition and food science journal to offer Registered Reports
The journal invites submission of high-quality original research articles and methods papers presenting cutting-edge scientific advances as well as review articles on current topics in all areas of nutrition and food science. The journal particularly invites submission of articles that deal with research at the interface of nutrition and food science and thus connects both disciplines.
Submit your work to NFS Journal to receive global visibility of your research.
The open-access journal will feature a new article format Registered Reports, which allows researchers to submit their innovative hypotheses and experimental procedures for testing them, and have them evaluated by members of the editorial board and outside expert reviewers before they begin their laboratory work. This creates the opportunity to receive feedback from peers, correct mistakes and optimise experiments, which in turn enhances the quality of the generated data.
If the pre-registered hypotheses and procedures adhere to the highest scientific standards, are positively evaluated by the peers, and the registered procedures are followed strictly, the acceptance of the Registered Report is guaranteed irrespective of the outcome of the study, thus eliminating publication bias once and for all.
When analysing your data, you may discover novel aspects that are exciting, but were not part of the pre-registered procedures. In order for authors to react to such unforeseen and exciting results and to explore new paths that have not been anticipated, it will be possible to include additional exploratory analyses in a special section of the Registered Reports.
Paper of the year 2014
Our paper The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes was the article with the most downloads from the website of Molecular Nutrition and Food Research in 2014 and therefore selected as the journal’s Paper of the year 2014. Even in 2015, the paper remained at the top of the list of highly accessed articles published in Molecular Nutrition and Food Research.
In this article, the lead authors Christina Schiborr and Alexa Kocher report the results of a crossover human trial identifying micellar solubilisation as a technique to increase the oral bioavailability of curcumin 185-fold over native curcumin.