Original articles

Original articles | Review articles | Book chapters | Doctoral theses

61. Podszun, M. C., Jakobi, M., Birringer, M., Weiss, J. & Frank, J. (2016). The long chain α–tocopherol metabolite α-13’-COOH and γ-tocotrienol induce P-glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180. Mol Nutr Food Res (in press), IF 4.551. 

60. Frank, J., Schiborr, C., Kocher, A., Meins, J., Behnam, D., Schubert-Zsilavecz, M., & Abdel-Tawab, M. (2017). Transepithelial transport of curcumin in Caco-2 cells is significantly enhanced by micellar solubilisation. Plant Foods for Human Nutrition 72: 48-53, IF 2.276.

59. Hanschke, N., Kankofer, M., Locher, L., Höltershinken, M., Meyer, U., Frank, J., Dänicke, S. & Rehage, J. (2016). The effect of conjugated linoleic acid (CLA) supplements on oxidative and antioxidative status of dairy cows. Journal of Dairy Science 99: 8090-8102IF 2.573.

58. Hagl, S., Asseburg, H., Heinrich, M., Sus, N., Blumrich, E.-M., Dringen, R., Frank, J. & Eckert, G. P. (2016). Effects of long-term Rice Bran Extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. NeuroMolecular Medicine 18: 347-363, IF 3.678.

57. Dützmann, S., Schiborr, C., Kocher, A., Pilatus, U., Hattingen, E., Weissenberger, J., Gessler, F., Quick-Weller, J., Franz, K., Seifert, V., Frank, J. & Senft, C. (2016) Intratumoral concentrations and effects of orally administered micellar curcuminoids in glioblastoma patients. Nutr Cancer 68: 943-948, IF 2.322.

56. Kocher, A., Bohnert, L., Schiborr, C. & Frank, J. (2016) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidaemic individuals. Mol Nutr Food Res 60: 1555-1563, IF 4.551.

55. Bortel, N., Armeanu-Ebinger, S., Schmid, E., Kirchner, B., Frank, J., Kocher, A., Schiborr, C., Warmann, S.W., Fuchs, J. & Ellerkamp, V.  (2015). Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB and the beta-catenin pathways. Oncotarget 6: 40680–40691, IF 6.359.

54. Hagl, S., Berressem, D., Bruns, B., Sus, N., Frank, J., & Eckert, G. P. (2015) Beneficial effects of ethanolic and hexanic rice bran extract on mitochondrial function in PC12 cells and the search for bioactive components. Molecules 20: 16524-16539, IF 2.416.

53. Hagl, S., Kocher, A., Schiborr, C., Kolesova, N., Frank, J., & Eckert, G. P. (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochemistry International 89: 234-242, IF 3.092.

52. Hagl, S., Berressem, D., Grewal, R., Sus, N., Frank, J., & Eckert, G. P. (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutritional Neuroscience 19: 1-10, IF 2.274.

51. Sadri, H., Dänicke, S., Rehage, J., Frank, J., & Sauerwein, H. (2015) Tocopherols and tocotrienols in serum and liver of dairy cows receiving conjugated linoleic acids or a control fat supplement during early lactation. Journal of Dairy Science 98: 7034-7043, IF 2.573.

50. Kocher, A., Hagl, S., Schiborr, C., Eckert, G. P., & Frank, J. (2015) Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice. NFS Journal 1: 3-8.

49. Kocher, A., Schiborr, C., Behnam, D., & Frank, J. (2015). The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol. J Funct Foods 14: 183-191, IF 3.574.

48. Moazzami, A. A., Frank, S., Gombert, A., Sus, N., Bayram, B., Rimbach, G., & Frank, J. (2015). Non-targeted 1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats. Food & Function 6: 1090-1097, IF 2.907.

47. Hongsibsong, S., Stuetz, W., Sus, N., Prapamontol, T., Grune, T., & Frank, J. (2014). Dietary exposure to continuous small doses of alpha-cypermethrin in the presence or absence of dietary curcumin does not induce oxidative stress in male Wistar rats. Toxicology Reports 1: 1106-1114.

46. Hagl, S., Heinrich, M., Kocher, A., Schiborr, C., Frank, J., & Eckert, G. P. (2014). Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer's disease. The Journal of Prevention of Alzheimer’s Disease 1: 80-83.

45. Chin, D., Hagl, S., Höhn, A., Huebbe, P., Pallauf, K., Grune, T., Frank, J., Eckert, G. P. & Rimbach, G. (2014). Adenosine triphosphate concentrations are higher in the brain of APOE3 compared to APOE4 targeted-replacement mice and can be modulated by curcumin. Genes & Nutrition 9: 397, IF 3.329.

44. Chin, D., Huebbe, P., Frank, J., Rimbach, G., & Pallauf, K. (2014). Curcumin may impair iron status when fed to mice for six months. Redox Biology 2: 563-569.

43. Podszun, M. C., Grebenstein, N., Spruss, A., Schlueter, T., Kremoser, C., Bergheim, I., & Frank, J. (2014). Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid-accumulation and down-regulate CD36 protein in the liver of guinea pigs. J Nutr Biochem 25: 573-579, IF 4.592.

42. Grebenstein, N., Schumacher, M., Graeve, L., & Frank, J. (2014). α-Tocopherol transfer protein is not required for the discrimination against γ-tocopherol in vivo but protects it from side-chain degradation in vitro. Mol Nutr Food Res 58: 1052-1060, IF 4.909.

41. Schiborr, C., Kocher, A., Behnam, D., Jandasek, J., Toelstede, S., & Frank, J. (2014). The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res 58: 516-527, IF 4.909.

40. Bayram, B., Rimbach, G., Frank, J., & Esatbeyoglu, T. (2014). A rapid method for glutathione quantification with potential application to glutathione disulfide, uric acid and ascorbic acid using high-performance liquid chromatography with coulometric electrochemical detection. J Agric Food Chem 62: 402-408, IF 2.906.

39. Mohrenz, I. V., Antonietti, P., Pusch, S., Capper, D., Balss, J., Voigt, S., Weissert, S., Mukrowsky, A., Frank, J., Senft, C., Seifert, V., vom Deimling, A., & Koegel, D. (2013) Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU- induced oxidative stress and cell death. Apoptosis 18: 1416-1425, IF 3.949.

38. Hagl, S., Kocher, A., Schiborr, C., Eckert, S., Ciobanu, I., Birringer, M., El-Askary, H., Helal, A., Khayyal, M. T., Frank, J., Müller, W. E., & Eckert, G. P. (2013) Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res 76: 17-27, IF 4.436 

37. Schiborr, C., Schwamm, D., Kocher, A., Rimbach, G., Eckert, G. P., & Frank J. (2013) The senescence-accelerated mouse - prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals. Pharmacol Res 74: 113-120, IF 4.436

36. Eckert, G. P., Schiborr, C., Hagl, S., Abdel-Kader, R., Müller, W. E., Rimbach, G., & Frank, J. (2013). Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8. Neurochemistry International 65: 595-602, IF 2.857.

35. Podszun, M. C., Grebenstein, N., Hofmann, U., & Frank, J. (2013). High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs. Toxicology and Applied Pharmacology 266: 452-458, IF 4.447.

34. Bayram, B., Ozcelik, B., Frank, J., & Rimbach, G. (2013). A Validated Method for the Determination of Selected Phenolics in Olive Oil Using High-Performance Liquid Chromatography with Coulometric Electrochemical Detection and a Fused-Core Colum. Food Chemistry 138: 1663-1669, IF 3.655.

33. Bayram, B., Esatbeyoglu, T., Schulze, N., Ozcelik, B., Frank, J., & Rimbach, G. (2012). Comprehensive Analysis of Polyphenols in 55 Extra Virgin Olive Oils by HPLC-ECD and Their Correlation with Antioxidant Activities. Plant Foods for Human Nutrition 67: 326-336, IF 2.505.  

32. Bayram, B., Nikolai, S., Huebbe, P., Ozcelik, B., Grimm, S., Grune, T., Frank, J., & Rimbach, G. (2012). Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence accelerated mouse prone 8. Age 35: 1205-1217, IF 3.948.

31. Grebenstein, N. & Frank, J. (2012) Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid-chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver. J Chromatogr A 1243: 39-46, IF 4.531. 

30. Egert, S., Tereszczuk, J., Wein, S., Müller, M.J., Frank, J., Rimbach, G. & Wolffram, S. (2013) Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. Eur J Nutr 52: 281-288, IF 2.750. 

29. Bayram, B., Ozcelik, B., Grimm, S., Roeder, T., Schrader, C., Ernst, I., Wagner, A., Grune, T., Frank, J. & Rimbach, G.  (2012). A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Research 15: 71-81, IF 3.826.

28. Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanovic, I., Laue, C., Winkler, P., Rüfer, C., Frank, J., Boesch-Saadatmandi, C., Rimbach, G. & Schrezenmeir, J. (2013). Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. Nutrition, Metabolism and Cardiovascular Disease 23: 403-409 , IF 3.731.

27. Boesch-Saadatmandi, C., Rimbach, G., Jungblut, A. & Frank, J. (2011) Comparison of tetrahydrofuran, fetal calf serum, and Tween 40 for the delivery of astaxanthin and canthaxanthin to HepG2 cells. Cytotechnology 63: 89-98, IF 1.207.

26. Schrader, C., Schiborr, C., Frank, J. & Rimbach, G. (2011) Curcumin induces paraoxonase-1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Brit J Nutr 105: 167-170, IF 3.072.

25. Schiborr, C., Eckert, G. P., Weissenberger, J., Müller, W. E., Schwamm, D., Grune, T., Rimbach, G. & Frank, J. (2010) Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharmaceut Biotechnol 11: 861-867, IF 3.455.

24. Schiborr, C., Eckert, G. P., Rimbach, G. & Frank, J. (2010) A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 397: 1917-25, IF 3.841. 

23. Fischer, A., Gaedicke, S., Frank, J., Döring, F. & Rimbach, G. (2010) Dietary vitamin E deficiency does not affect global and specific DNA methylation pattern in rat liver. Brit J Nutr 104: 935-940, IF 3.072.

22. Egert, S., Bosy-Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta-Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G., Wolffram, S. & Müller, M. J. (2009) Quercetin reduces systolic blood pressure and plasma oxidized LDL concentrations in overweight subjects with a high-CVD-risk phenotype: a double-blinded, placebo-controlled crossover study. Brit J Nutr 102: 1065-1074, IF 3.446.

21. Augustin, K., Frank, J., Augustin, S., Langguth, P., Öhrvik, V., Witthöft, C., Rimbach, G. & Wolffram, S. (2009) Green tea extracts lower 5-methyltetrahydrofolate in rats only at very high dietary concentrations and do not affect folate concentrations in a human pilot study. J Physiol Pharmacol 60: 103-108, IF 2.631.

20. Wiegand, H., Bösch-Saadatmandi, C., Wein, S., Wolffram, S., Frank, J. & Rimbach, G. (2010) Dietary flavonoids do not affect vitamin E status in growing rats. J Anim Phsyiol Anim Nutr 94: 307-318 (published online in 2009), IF 1.106.

19. Gaedicke, S., Zhang, X., Huebbe, P., Boesch-Saadatmandi, C., Lou, Y., Wiswedel, I., Gardemann, A., Frank, J. & Rimbach, G. (2009) Dietary vitamin E, brain redox status and expression of Alzheimer’s disease relevant genes in rats. Brit J Nutr 102: 398-406, IF 3.446.

18. Frank, J., George, T. W., Lodge, J. K., Rodriguez-Mateos, A., Spencer, J. P. E., Minihane, A. M., & Rimbach, G. (2009) Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease-risk biomarkers in healthy men. J Nutr 139: 58-62, IF 3.647.

17. Gaedicke, S., Zhang, X., Schmelzer, C., Lou, Y., Doering, F., Frank, J. & Rimbach, G. (2008) Vitamin E dependent microRNA regulation in rat liver. FEBS Lett 582: 3542-3546, IF 3.264. 

16. Egert, S., Wolffram, S., Bosy-Westphal, A., Bösch-Saadatmandi, C., Wagner, A., Frank, J., Rimbach, G. & Müller, M. J. (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138: 1615-1621, IF 3.647.

15. Frank, J., Lee, S., Leonard, S. W., Atkinson, J. K., Kamal-Eldin, A. & Traber, M. G. (2008) Sex differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am J Clin Nutr 87: 1723-1729, IF 6.740.

14. Augustin, K., Blank, R., Boesch-Saadatmandi, C., Frank, J., Wolffram, S. & Rimbach, G. (2008) Dietary green tea polyphenols do not affect vitamin E-status, antioxidant capacity and meat quality of growing pigs. J Anim Physiol Anim Nutr 92: 705-711, IF 0.911.

13. Jofre-Monseny, L., Huebbe, P., Stange, I., Boesch-Saadatmandi, C., Frank, J., Jackson, K., Minihane, A. M. & Rimbach, G. (2007) Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein in apoE3 and apoE4 targeted replacement mice. Brit J Nutr 100: 44-53, IF 2.339. 

12. Moazzami, A. A., Frank, J., Lundh, T., Vessby, B. & Kamal-Eldin, A. (2007) Dietary Phytosterols Inhibit the Lipid Modulating Effects of Sesamin in Rats. Curr Topics Nutraceut Res 5: 93-98, IF 0.529.

11. Frank, J., Budek, A., Lundh, T., Parker, R. S., Swanson, J. E., Lourenco, B., Gago, J., Laranjinha, J., Vessby, B. & Kamal-Eldin, A. (2006) Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro. J Lipid Res 47: 2718-2725, IF 4.357. 

10. Hundhausen, C., Frank, J., Rimbach, G., Stoecklin, E., Muller, P. Y. & Barella, L. (2006) Effect of Vitamin E on Cytochrome P450 mRNA Levels in Cultured Hepatocytes (HepG2) and in Rat Liver. Cancer Genomics & Proteomics 3: 183-190.

9. Müller, P.Y., Netscher, T., Frank, J., Stöcklin, E., Rimbach, G., & Barella, L. (2005) Comparative Quantification of Pharmacodynamic Parameters of Chiral Compounds by Global Gene Expression Profiling. J Plant Physiol 162: 811-817, IF 1.403.

8. Frank, J., Kamal-Eldin, A. & Traber, M. G. (2004) Consumption of Sesame Oil Muffins Decreases the Urinary Excretion of γ-Tocopherol Metabolites in Humans. Ann N Y Acad Sci 1031: 365-367, IF 1.789.

7. Frank, J., Eliasson, C., Leroy-Nivard, D., Budek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats. Brit J Nutr 92: 169-176, IF 2.710.

6. Frank, J., Sundberg, B., Kamal-Eldin, A., Vessby, B. & Åman, P. (2004) Yeast-Leavened Oat Breads with High or Low Molecular Weight β-Glucan Do Not Differ in Their Effects on Blood Concentrations of Lipids, Insulin, or Glucose in Humans. J Nutr 134: 1384-1388, IF 3.245.

5. Ross, A. B., Chen, Y., Frank, J., Swanson, J. E., Parker, R. S., Kozubek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Cereal Alkylresorcinols Elevate γ-Tocopherol Levels in Rats and Inhibit γ-Tocopherol Metabolism In Vitro. J Nutr 134: 506-510, IF 3.245.

4. Frank, J., Lundh, T., Parker, R. S., Swanson, J. E., Vessby, B. & Kamal-Eldin, A. (2003) Dietary (+)-Catechin and BHT Markedly Increase α-Tocopherol Concentrations in Rats by a Tocopherol-ω-Hydroxylase-Independent Mechanism. J Nutr 133: 3195-3199, IF 3.321.

3. Frank, J., Kamal-Eldin, A., Razdan, A., Lundh, T. & Vessby, B. (2003) The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenic acid increase vitamin E and cholesterol concentrations in Sprague-Dawley rats. J Agric Food Chem 51: 2526-2531, IF 2.102. 

2. Frank, J., Kamal-Eldin, A., Lundh, T., Määttä, K., Törrönen, R. & Vessby, B. (2002) Effects of Dietary Anthocyanins on Tocopherols and Lipids in Rats. J Agric Food Chem 50: 7226-7230, IF 1.915.

1. Kamal-Eldin, A., Frank, J., Razdan, A., Tengblad, S., Basu, S. & Vessby, B. (2000) Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 35: 427-435, IF 1.769. 

Original articles | Review articles | Book chapters | Doctoral theses