Alexa Kocher, Ph.D.


July 2015 - Dr. rer. nat. (Ph.D.) in Nutritional Sciences, University of Hohenheim, Stuttgart, Germany
Thesis: Curcumin - Bioavailability and bioactivity in relation to aging

2010 - Diploma in Nutritional Sciences (equivalent to M.Sc.), University of Hohenheim, Stuttgart, Germany

Professional experience

October 2015 - present: Clinical Research Assistant, Mainz, Germany

August - September 2015: Postdoctoral researcher,  Division Biofunctionality and Safety of Food, Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany

February 2011 - July 2015: Docotoral student,  Division Biofunctionality and Safety of Food, Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany

August 2014 - April 2015: Guest researcher, Department of Chemical and Biological Engineering, Chalmers Technical University, Gothenburg, Sweden

Awards and affiliations

October 2013 - Poster prize at the Sixth International Conference on Polyphenols and Health (ICPH 2013), Buenos Aires, Argentina

Member of the Society of Nutrition and Food Science


Original articles

Dützmann, S., Schiborr, C., Kocher, A., Pilatus, U., Hattingen, E., Weissenberger, J., Gessler, F., Quick-Weller, J., Franz, K., Seifert, V., Frank, J. & Senft, C. (2016) Intratumoral concentrations and effects of orally administered micellar curcuminoids in glioblastoma patients. Nutrition and Cancer (published online ahead of print), IF 2.322.

Kocher, A., Bohnert, L., Schiborr, C. & Frank, J. (2016) Highly bioavailable micellar curcuminoids accumulate in blood, are safe and do not reduce blood lipids and inflammation markers in moderately hyperlipidaemic individuals. Mol Nutr Food Res (published online ahead of print), IF 4.603.

Bortel, N., Armeanu-Ebinger, S., Schmid, E., Kirchner, B., Frank, J., Kocher, A., Schiborr, C., Warmann, S.W., Fuchs, J. & Ellerkamp, V.  (2015). Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB and the beta-catenin pathways. Oncotarget (accepted for publication), IF 6.359.

Hagl, S., Kocher, A., Schiborr, C., Kolesova, N., Frank, J., & Eckert, G. P. (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochemistry International, (published online), IF 3.092.

Kocher, A., Hagl, S., Schiborr, C., Eckert, G. P., & Frank, J. (2015) Concentrations of total curcuminoids in plasma, but not liver and kidney, are higher in 18- than in 3-months old mice. NFS Journal 1: 3-8.

Kocher, A., Schiborr, C., Behnam, D., & Frank, J. (2015). The oral bioavailability of curcuminoids in healthy humans is markedly enhanced by micellar solubilisation but not further improved by simultaneous ingestion of sesamin, ferulic acid, naringenin and xanthohumol. J Funct Foods 14: 183-191, IF 4.480.

Hagl, S., Heinrich, M., Kocher, A., Schiborr, C., Frank, J., & Eckert, G. P. (2014). Curcumin micelles improve mitochondrial function in a mouse model of Alzheimer's disease. The Journal of Prevention of Alzheimer’s Disease 1: 80-83.

Schiborr, C., Kocher, A., Behnam, D., Jandasek, J., Toelstede, S., & Frank, J. (2014). The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res 58: 516-527, IF 4.909.

Hagl, S., Kocher, A., Schiborr, C., Eckert, S., Ciobanu, I., Birringer, M., El-Askary, H., Helal, A., Khayyal, M. T., Frank, J., Müller, W. E., & Eckert, G. P. (2013) Rice bran extract protects from mitochondrial dysfunction in guinea pig brains. Pharmacol Res 76: 17-27, IF 4.436 

Schiborr, C., Schwamm, D., Kocher, A., Rimbach, G., Eckert, G. P., & Frank J. (2013) The senescence-accelerated mouse - prone 8 is not a suitable model for the investigation of cardiac inflammation and oxidative stress and their modulation by dietary phytochemicals. Pharmacol Res 74: 113-120, IF 4.436

Book chapters

Kocher, A., Schiborr, C., Weber, D., Grune, T. & Frank, J. (2013) The bioavailability and antioxidant activity of curcuminoids and carotenoids in humans. In: "Food Oxidants and Antioxidants: Chemical, Biological, and Functional Properties", Bartosz, G., ed., CRC Press (ISBN 978-1-439-88241-2).