Human Metabolomics

36. Eckert, G. P., Schiborr, C., Hagl, S., Abdel-Kader, R., Müller, W. E., Rimbach, G., & Frank, J. (2013). Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse - prone 8. Neurochemistry International 65: 595-602, IF 2,857.

35. Podszun, M. C., Grebenstein, N., Hofmann, U., & Frank, J. (2013). High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs. Toxicology and Applied Pharmacology 266: 452-458, IF 4,447.

34. Bayram, B., Ozcelik, B., Frank, J., & Rimbach, G. (2013). A Validated Method for the Determination of Selected Phenolics in Olive Oil Using High-Performance Liquid Chromatography with Coulometric Electrochemical Detection and a Fused-Core Colum. Food Chemistry 138: 1663-1669, IF 3,655.

33. Bayram, B., Esatbeyoglu, T., Schulze, N., Ozcelik, B., Frank, J., & Rimbach, G. (2012). Comprehensive Analysis of Polyphenols in 55 Extra Virgin Olive Oils by HPLC-ECD and Their Correlation with Antioxidant Activities. Plant Foods for Human Nutrition 67: 326-336, IF 2,505. 

32. Bayram, B., Nikolai, S., Huebbe, P., Ozcelik, B., Grimm, S., Grune, T., Frank, J., & Rimbach, G. (2012). Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence accelerated mouse prone 8. Age (online publiziert), IF 3,948.

31. Grebenstein, N. & Frank, J. (2012) Rapid baseline-separation of all eight tocopherols and tocotrienols by reversed-phase liquid-chromatography with a solid-core pentafluorophenyl column and their sensitive quantification in plasma and liver. J Chromatogr A 1243: 39-46, IF 4,531. 

30. Egert, S., Tereszczuk, J., Wein, S., Müller, M.J., Frank, J., Rimbach, G. & Wolffram, S. (2012) Simultaneous ingestion of dietary proteins reduces the bioavailability of galloylated catechins from green tea in humans. Eur J Nutr 52: 281-288, IF 3,343. 

29. Bayram, B., Ozcelik, B., Grimm, S., Roeder, T., Schrader, C., Ernst, I., Wagner, A., Grune, T., Frank, J. & Rimbach, G.  (2012). A diet rich in olive oil phenolics reduces oxidative stress in the heart of SAMP8 mice by induction of Nrf2-dependent gene expression. Rejuvenation Research 15: 71-81, IF 3,826

28. Pfeuffer, M., Auinger, A., Bley, U., Kraus-Stojanovic, I., Laue, C., Winkler, P., Rüfer, C., Frank, J., Boesch-Saadatmandi, C., Rimbach, G. & Schrezenmeir, J. (2013). Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammatory parameters in men with different APOE isoforms. Nutrition, Metabolism and Cardiovascular Disease 23: 403-409, IF 3,731.

27. Boesch-Saadatmandi, C., Rimbach, G., Jungblut, A. & Frank, J. (2011) Comparison of tetrahydrofuran, fetal calf serum, and Tween 40 for the delivery of astaxanthin and canthaxanthin to HepG2 cells. Cytotechnology 63: 89-98, IF  1,207.

26. Schrader, C., Schiborr, C., Frank, J. & Rimbach, G. (2011) Curcumin induces paraoxonase-1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Brit J Nutr 105: 167-170, IF 3,072.

25. Schiborr, C., Eckert, G. P., Weissenberger, J., Müller, W. E., Schwamm, D., Grune, T., Rimbach, G. & Frank, J. (2010) Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharmaceut Biotechnol 11: 861-867, IF 3,455. 

24. Schiborr, C., Eckert, G. P., Rimbach, G. & Frank, J. (2010) A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem 397: 1917-25, IF 3,841.

23. Fischer, A., Gaedicke, S., Frank, J., Döring, F. & Rimbach, G. (2010) Dietary vitamin E deficiency does not affect global and specific DNA methylation pattern in rat liver. Brit J Nutr 104: 935-940, IF 3,072.

22. Egert, S., Bosy-Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta-Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G., Wolffram, S. & Müller, M. J. (2009) Quercetin reduces systolic blood pressure and plasma oxidized LDL concentrations in overweight subjects with a high-CVD-risk phenotype: a double-blinded, placebo-controlled crossover study. Brit J Nutr 102: 1065-1074, IF 3,446.

21. Augustin, K., Frank, J., Augustin, S., Langguth, P., Öhrvik, V., Witthöft, C., Rimbach, G. & Wolffram, S. (2009) Green tea extracts lower 5-methyltetrahydrofolate in rats only at very high dietary concentrations and do not affect folate concentrations in a human pilot study.J Physiol Pharmacol 60: 103-108, IF 2,631. 

20. Wiegand, H., Bösch-Saadatmandi, C., Wein, S., Wolffram, S., Frank, J. & Rimbach, G. (2010) Dietary flavonoids do not affect vitamin E status in growing rats. J Anim Phsyiol Anim Nutr 94: 307-318 (online in 2009), IF 1,106.

19. Gaedicke, S., Zhang, X., Huebbe, P., Boesch-Saadatmandi, C., Lou, Y., Wiswedel, I., Gardemann, A., Frank, J. & Rimbach, G. (2009) Dietary vitamin E, brain redox status and expression of Alzheimer’s disease relevant genes in rats. Brit J Nutr 102: 398-406, IF 3,446. 

18. Frank, J., George, T. W., Lodge, J. K., Rodriguez-Mateos, A., Spencer, J. P. E., Minihane, A. M., & Rimbach, G. (2009) Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease-risk biomarkers in healthy men. J Nutr 139: 58-62, IF 3,647.

17. Gaedicke, S., Zhang, X., Schmelzer, C., Lou, Y., Doering, F., Frank, J. & Rimbach, G. (2008) Vitamin E dependent microRNA regulation in rat liver. FEBS Lett 582: 3542-3546, IF 3,264.

16. Egert, S., Wolffram, S., Bosy-Westphal, A., Bösch-Saadatmandi, C., Wagner, A., Frank, J., Rimbach, G. & Müller, M. J. (2008) Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr 138: 1615-1621, IF 3,647.

15. Frank, J., Lee, S., Leonard, S. W., Atkinson, J. K., Kamal-Eldin, A. & Traber, M. G. (2008) Sex differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am J Clin Nutr 87: 1723-1729, IF 6,740.

14. Augustin, K., Blank, R., Boesch-Saadatmandi, C., Frank, J., Wolffram, S. & Rimbach, G. (2008) Dietary green tea polyphenols do not affect vitamin E-status, antioxidant capacity and meat quality of growing pigs. J Anim Physiol Anim Nutr 92: 705-711, IF 0,911.

13. Jofre-Monseny, L., Huebbe, P., Stange, I., Boesch-Saadatmandi, C., Frank, J., Jackson, K., Minihane, A. M. & Rimbach, G. (2007) Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein in apoE3 and apoE4 targeted replacement mice. Brit J Nutr 100: 44-53, IF 2,339.

12. Moazzami, A. A., Frank, J., Lundh, T., Vessby, B. & Kamal-Eldin, A. (2007) Dietary Phytosterols Inhibit the Lipid Modulating Effects of Sesamin in Rats.Curr Topics Nutraceut Res 5: 93-98, IF 0,529.

11. Frank, J., Budek, A., Lundh, T., Parker, R. S., Swanson, J. E., Lourenco, B., Gago, J., Laranjinha, J., Vessby, B. & Kamal-Eldin, A. (2006) Dietary flavonoids with a catechol structure increase α-tocopherol in rats and protect the vitamin from oxidation in vitro. J Lipid Res 47: 2718-2725, IF 4,357.

10. Hundhausen, C., Frank, J., Rimbach, G., Stoecklin, E., Muller, P. Y. & Barella, L. (2006) Effect of Vitamin E on Cytochrome P450 mRNA Levels in Cultured Hepatocytes (HepG2) and in Rat Liver. Cancer Genomics & Proteomics 3: 183-190.

9. Müller, P.Y., Netscher, T., Frank, J., Stöcklin, E., Rimbach, G., & Barella, L. (2005) Comparative Quantification of Pharmacodynamic Parameters of Chiral Compounds by Global Gene Expression Profiling. J Plant Physiol 162: 811-817, IF 1,403.

8. Frank, J., Kamal-Eldin, A. & Traber, M. G. (2004) Consumption of Sesame Oil Muffins Decreases the Urinary Excretion of γ-Tocopherol Metabolites in Humans. Ann N Y Acad Sci 1031: 365-367, IF 1,789.

7. Frank, J., Eliasson, C., Leroy-Nivard, D., Budek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats. Br J Nutr 92: 169-176, IF 2,710.

6. Frank, J., Sundberg, B., Kamal-Eldin, A., Vessby, B. & Åman, P. (2004) Yeast-Leavened Oat Breads with High or Low Molecular Weight β-Glucan Do Not Differ in Their Effects on Blood Concentrations of Lipids, Insulin, or Glucose in Humans. J Nutr 134: 1384-1388, IF 3,245.

5. Ross, A. B., Chen, Y., Frank, J., Swanson, J. E., Parker, R. S., Kozubek, A., Lundh, T., Vessby, B., Åman, P. & Kamal-Eldin, A. (2004) Cereal Alkylresorcinols Elevate γ-Tocopherol Levels in Rats and Inhibit γ-Tocopherol Metabolism In Vitro. J Nutr 134: 506-510, IF 3,245.

4. Frank, J., Lundh, T., Parker, R. S., Swanson, J. E., Vessby, B. & Kamal-Eldin, A. (2003) Dietary (+)-Catechin and BHT Markedly Increase α-Tocopherol Concentrations in Rats by a Tocopherol-ω-Hydroxylase-Independent Mechanism. J Nutr 133: 3195-3199, IF 3,321.

3. Frank, J., Kamal-Eldin, A., Razdan, A., Lundh, T. & Vessby, B. (2003) The dietary hydroxycinnamate caffeic acid and its conjugate chlorogenic acid increase vitamin E and cholesterol concentrations in Sprague-Dawley rats. J Agric Food Chem 51: 2526-2531, IF 2,102.

2. Frank, J., Kamal-Eldin, A., Lundh, T., Määttä, K., Törrönen, R. & Vessby, B. (2002) Effects of Dietary Anthocyanins on Tocopherols and Lipids in Rats. J Agric Food Chem 50: 7226-7230, IF 1,915.

1. Kamal-Eldin, A., Frank, J., Razdan, A., Tengblad, S., Basu, S. & Vessby, B. (2000) Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids 35: 427-435, IF 1,769.

6. Frank, J., Chin, D., Schrader, C., Eckert, G.P. & Rimbach, G. (2011) Do tocotrienols have potential as neuroprotective dietary factors? Ageing Research Reviews 11: 163-180, IF 6,174.

5. Frank, J. & Rimbach, G. (2009) Vitamin E in disease prevention – a critical appraisal of vitamin E supplementation trials. Aktuelle Ernährungsmedizin 34: 131-140.

4. Rimbach, G., Boesch-Saadatmandi, C., Frank, J., Fuchs, D., Wenzel, U., Daniel, H., Hall, W. & Weinberg, P. D. (2007) Dietary isoflavones in the prevention of cardiovascular disease – A molecular perspective. Food Chem Toxicol 46: 1308-1319, IF 2,114.

3. Frank J. (2007) Einfluss von Nahrungspolyphenolen auf den Vitamin-E-Status (Influence of dietary polyphenols on vitamin E-status). Ernährungs-Umschau: 54:52-9.

2. Frank, J., de Pascual Teresa, S. & Rimbach, G. (2006) Nutrigenomics – new frontiers in antioxidant research. Food Sci Technol Bull: Functional Foods 3 (1) 1-12.

1. Frank, J. (2005) Beyond vitamin E supplementation: An alternative strategy to improve vitamin E status. J Plant Physiol 162: 834-843, IF 2,500.

2. Kocher, A., Schiborr, C., Weber, D., Grune, T. & Frank, J. (2012) The bioavailability and antioxidant activity of curcuminoids and carotenoids in humans. In: "Food Oxidants and Antioxidants: Chemical, Biological, and Functional Properties", Bartosz, G., ed., CRC Press (ISBN 978-1-439-88241-2, im Druck).  

1. Frank, J. & Rimbach, G. (2009) Nutrigenomics. In: “Chemoprevention of Cancer and DNA Damage by Dietary Factors”, Knasmüller, S., DeMarini, D. M., Johnson, I. T. & Gerhäuser, C., eds., Wiley-VCH (ISBN: 978-3-527-32058-5): 303-333.

Frank, J. (2004) Dietary Phenolic Compounds and Vitamin E Bioavailability - Model studies in rats and humans.Doctoral dissertation.  Department of Food Science, Swedish University of Agricultural Sciences (SLU). Acta Universitatis Agriculturae Suecia. Agraria vol. 446. ISSN 1401-6249, ISBN 91-576-6453-6.URL: http://diss-epsilon.slu.se/archive/00000558/